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The aim of this research is to assess the benefit of treatment with bupropion, mirtazapine or reboxetine in treating the acute phase of depression, in maintenance therapy (relapse prevention), and in recurrence prevention compared to treatment with placebo each other treatment with other antidepressants in each case in adult patients with depression.
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Smokers were excluded for current serious neurologic, psychiatric, or medical illness (as assessed by the study physician); sharing immediate work environment with a current or past participant; current alcohol dependence; current major depressive episode; history of anorexia nervosa or bulimia; current use of psychoactive medications; history of seizure disorder; previous hypersensitivity to bupropion; or current use of smokeless tobacco, pipes, cigars, nicotine replacement products, or marijuana.
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