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The first was a February 13, 2008 study by Aubin () - This 52 week Pfizer funded study compared 12 weeks of varenicline (1mg twice daily) by 376 users, to 10 weeks of stepped-down nicotine patch use (21mg to 7mg patches) by 370 patch users.

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Five of the six studies were randomized, controlled clinical trials in which Chantix was shown to be superior to placebo in helping people quit smoking.

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