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How are cytotoxic agents toxic? Cytotoxic drugs have both anti-cancer activity and the potential to damage normal tissue; most cytotoxic drugs are teratogenic. All cytotoxic drugs cause side-effects and a balance has to be struck between likely benefit and acceptable toxicity.
What are the side effects of cytotoxic drugs? Common side-effects of cytotoxic drugs include fatigue, reversible alopecia, nausea and vomiting, oral ulceration, diarrhoea, skin rashes, bone marrow suppression and effects on fertility. Possible effects on fertility and gonadal function must be discussed before treatment begins.
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