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His doctor recently started him on Plavix.

The dose could be reduced to 50 mg twice daily if patients experienced an adverse event that might have been drug related.

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However, to the best of our knowledge, there has been no clear guideline on which percent increase of INR is clinically safe or risky.

Antidepressants, especially noradrenergic agents, are useful for depression-related apathy.

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The committee will be asked to discuss the potential clinical utility of fixed-combination prescription drugs composed of an anti-hypertensive drug, aspirin, and a statin administered to reduce the risk of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke in patients with a history of cardiovascular disease.

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Given the small number of NAION events with PDE5 use (fewer than one in one million), the large number of users of PDE5 inhibitors (millions) and the fact that this event occurs in a similar population to those who do not take these medicines, the FDA concluded that they were not able to draw a cause and effect relationship, given these patients underlying vascular risk factors or anatomical defects.

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