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An antiviral drug, amantadine, also appears to reduce symptoms.
Early in the course of the disease, the degree of improvement in tremor, rigidity, and bradykinesia may be nearly complete.
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If the tremor is not controlled adequately with medication, surgical therapy may be considered at any time during the disease.
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The oxidation hypothesis suggests that free radical damage, resulting from dopamine's oxidative metabolism, plays a role in the development or progression of Parkinson disease.
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Allergic reactions (rash, swelling of the face or tongue, anaphylaxis) have been reported in clinical practice from both oseltamivir and zanamivir.
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In a study of 22 patients with mild, moderate, and severe traumatic brain injury, Kraus and colleagues showed improvements in executive function as well as an increase in glucose metabolism in the prefrontal cortex on positron emission tomography in patients taking amantadine.
Specific step-by-step recommendations for the clinical management of patients with TD, including algorithms, have been offered ( 6, 18, 38).
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